Alix Schmidt nackt sorted by

relevance

Interactions between Alix and the ESCRT machinery Significant advances in our understanding of the function of Alix have stemmed from characterization of other class E Vps proteins, many of which assemble into hetero-oligomeric endosomal sorting complexes required for transport ESCRTs , a group of complexes involved in sorting MVB cargoes reviewed by.

Nevertheless, Patch 2 contains the most highly conserved set of amino acids in the Bro1 domain, which suggests that this region performs an important function exploited by Src in mammalian cells and probably also in other metazoans - Xp95, the orthologue of Alix in Xenopus laevis, was originally identified as a phosphoprotein regulated by Src activity.

The roles of Alix have largely been inferred from the functions of proteins with which it interacts.

Proteins that can regulate seemingly disparate mechanisms do so by engaging in multiple distinct protein interaction networks.

Model for the negative regulation of EGFR endocytosis by Alix.

A role for Alix in this process was initially suggested by observations that the loss of Bro1 function in yeast impairs the downregulation of cell-surface proteins that normally undergo endocytosis and delivery to the vacuole, the functional equivalent of the lysosome in higher eukaryotes ;.

Instead, it accelerates virion production , and this is enhanced by overexpression of Alix.

More recent evidence has established that Alix has a hand in regulating other cellular mechanisms, including endocytic membrane trafficking and cell adhesion.

The Bro1 domain is built around a core of helices with a set of hydrophobic amino acids exposed on one side that comprise the Snf7-binding site.

AlixPartners is not a certified public accounting firm and is not authorized to practice law or provide legal services.